منابع مشابه
The glucagon content of crystalline insulin preparations.
Shortly after the discovery of insulin, investigators reported that intravenous administration of this hormone leads to a transient hyperglycemia. Kimball and Murlin (1) suggested that this response was caused by the presence of a second physiologically active substance which they named glucagon. Some workers (2, 3), however, suggested that this effect might be ascribed to insulin, or possibly ...
متن کاملIsolation of some crystalline yellow peptides from enzymic digests of dinitrophenyl insulin and dinitrophenyl trypsinogen.
Previous work has shown that the peptide-like growth factor strepogenin probably occurs in certain proteins such as insulin and trypsinogen at the amino end of the protein (l), and that it is liberated by suitable enzymic digestion. This conclusion suggested a means for attacking the almost insurmountable task involved in separating the one compound strepogenin from the mixture of numerous pept...
متن کاملCrystalline Suspension of Bovine Zinc Des-AlaB30-Insulin with Prolonged Hypoglycaemic Activity
The reversible reaction of cyclohexane-1,2-dione with the guanidino function of Arg-B22 in bovine insulin gave the dihydroxycyclohexylene [DHCH]-Arg-B22-insulin complex (I) which, after selective tryptic cleavage at the Lys-B29 residue and regeneration of the guanidino group, afforded bovine des-AlaB30-insulin (III) in an overal 85.80/o yield. The truncated insulin III was converted into the re...
متن کاملThe Inactivation of Crystalline Insulin by Cysteine and Glutathione* by Vincent
In some earlier work on insulin (1, 2) we have shown that the sulfur of insulin existed mainly if not entirely in the disulfide form, and further that the major portion of the disulfide content could be accounted for by cystine. In continuation of this study of the sulfur of insulin we felt it would be worth while to study the behavior of the reduced or sulfhydryl form of insulin. If the disulf...
متن کاملCrystalline Enzymes
In this monograph, Northrop summarizes the work on proteolytic enzymes and on the bacteriophage which has been carried out in his laboratory at the Rockefeller Institute for Medical Research in Princeton during the past ten years. After a brief introduction, dealing with the fundamentals of enzymatic catalysis, the preparation in crystalline or purified form and the properties of the following ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1935
ISSN: 0306-3283
DOI: 10.1042/bj0291048